Well, after giving a couple of VorTechs' updated tools a go and still feeling no love, then rolling back to earlier versions of the tools without luck, and ultimately repartitioning/reformatting the drive with the PhatHack CD, and trying to use it with PMM 3.51, 3.42, and 3.22, I can only report at this point that using a 250GB DMS with Media Manager is hit and miss at best.
Prior to reformatting with the Windows Tools, I thought I was at peace with 3.51, but now I think it was just luck. In all versions, most often the partitions will unmount before any write operations can be attempted. Even if it manages to fully load, the partitions unmount when any kind of write operation is attempted. Sometimes, it will seem to work, but then I try to transfer some tracks, nothing happens -- they cue up in the software, but they don't get transferred. I'll keep tinkering, and wait to see if a new iteration of the Windows Tools might take care of some of these issues.